There is a release of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors while in the dorsal horn to minimize afferent discomfort transmission and produce analgesia. Consequently, medications like clonidine that concentrate on alpha-2 receptors can influence the transmission of suffering. Applies to clonidine: oral pill, https://edmundn813ile6.blog5star.com/profile