There is a release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to lessen afferent pain transmission and make analgesia. Hence, drugs like clonidine that focus on alpha-2 receptors can influence the transmission of agony. Clonidine is distributed in breast milk; https://douglasu581xuq0.goabroadblog.com/profile